The purpose of this study was to explore the relationships among knowledge of insulin-dependent diabetes mellitus (IDDM), attitude toward diabetes, family and friends support, benefits of and barriers to treatment, and compliance with health regimens of Jordanian adolescents wit…
A high prevalence rate of IGT, together with the fact that a high number of diabetics were not identified before this study may be cause for alarm to the local health providers and also the population. With economic growth and the adoption of a westernized lifestyle, it is proba…
TNF-α acutely increases leptin production in animals and humans. Insulin-mediated glucose uptake potently regulates leptin production in adipocytes. Yet, TNF-α inhibits insulin signaling and decreases Akt expression, which was demonstrated to regulate leptin production in adipoc…
One central mechanism underlying cell death following cerebral ischemia is a loss of the balance between excitation and inhibition leading to excitotoxicity. We began by investigating whether oxygen-glucose deprivation (OGD), an ischemia-like challenge, altered cell-surface expr…
An implantable closed-loop insulin delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of 10 years, to mimic pancreas. In this thesis, the reliability and performance capability of the INsmart d…
Amaç: Bu çalışmada sıçanlarda streptozotosin ile oluşturulan diyabet modelinde kardiyovasküler komplikasyonları etkileyebilecek miRNA'ların kalp dokusundaki ekspresyon düzeylerine bakılması amaçlanmıştır. Gereç ve Yöntem: Çalışmamızda, 300-400 gr arasındaki ağırlıkta olan Spragu…
The study of molecular containers has accelerated dramatically since the 1960's. The introduction of cucurbit[n]urils has contributed tremendously and continues to contribute to the expansion of the field. Chapter 1 introduces cucurbit[n]urils and their molecular recognition pro…
In type 1 diabetes, insulin secretion is lost due to the autoimmune destruction of pancreatic beta cells, and life-long insulin therapy is needed to regulate blood glucose levels. Insulin therapy is currently implemented using either multiple daily injections with an insulin pen…