Thesiss

TNF-α acutely increases leptin production in animals and humans. Insulin-mediated glucose uptake potently regulates leptin production in adipocytes. Yet, TNF-α inhibits insulin signaling and decreases Akt expression, which was demonstrated to regulate leptin production in adipoc…

Obesity affects about 520 million people world-wide and more recently studies have shown that fat cells produce proteins called adipokines which have various influences on the human metabolism and has helped to change the perspectives of researchers on the concept of the adipose…

This research examines the metabolic and hormonal control of appetitive ingestive behavior in Syrian hamsters. Circulating metabolic fuels, leptin, insulin and levels of body fat change with metabolic challenges, and all have been implicated in the control of ingestive behavior.…

In females of most species including women, reproductive processes are inhibited by low food availability. The experiments in this thesis examined the role of glucose oxidation, the adipocyte protein, leptin, and the brain melanocortin receptor on food intake and reproduction, s…