TNF-α acutely increases leptin production in animals and humans. Insulin-mediated glucose uptake potently regulates leptin production in adipocytes. Yet, TNF-α inhibits insulin signaling and decreases Akt expression, which was demonstrated to regulate leptin production in adipoc…
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Epithelial ovarian cancer frequently metastasizes to the omentum, a process that requires pro-angiogenic activation of local microvascular endothelial cells (ECs) by tumour-secreted factors. We have previously shown that ovarian cancer cells secrete factors, other than vascular …
Phosphatidyl D-myo-inositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] contributes to the activation of protein kinase B (PKB) by interacting with the PKB PH domain. PKB is known to be up-regulated in several cancer cell types. Compounds that can display selective inhibition of thi…