Over the last century, the study of retroviruses has shed light on many different aspects of biology including cancer biology, gene regulation, RNA processing, cell survival and genome structure. In this thesis I have used unique features of retroviruses to gain more insight int…
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MicroRNAs are endogenous non-coding RNA (~22nt) that bind to the 3' untranslated region (UTR) of target messenger RNA (mRNA) and facilitate translational repression and degradation. Previous studies have demonstrated the essential role of miRNA in many biological processes, incl…