Thesiss

The Human Epidermal Growth Factor Receptor 2 (HER2) is an oncogene expressed in 25-30% of invasive breast cancers. The HER2 gene encodes an 185kDa transmembrane protein with tyrosine kinase activity. Gene amplification or protein expression of HER2 is a predictor of poor prognos…

Over the last century, the study of retroviruses has shed light on many different aspects of biology including cancer biology, gene regulation, RNA processing, cell survival and genome structure. In this thesis I have used unique features of retroviruses to gain more insight int…