Thesiss

Viable, rod-shaped, trypan blue-exclusive cardiac myocytes were purified from collagenase perfused heart. The cells showed typical cross-striations and rhythmical beating movements. This ceil preparation was used to demonstrate the existence of the soluble enzymes ATP-citrate ly…

Lysophosphatidic acid (LPA) is known to exert a diverse range of effects in humans, specifically in the heart where it may cause apoptosis of cardiomyocytes at pathological concentrations. However, at physiological concentrations LPA may regulate cell migration, proliferation an…

Amaç: Bu çalışmada sıçanlarda streptozotosin ile oluşturulan diyabet modelinde kardiyovasküler komplikasyonları etkileyebilecek miRNA'ların kalp dokusundaki ekspresyon düzeylerine bakılması amaçlanmıştır. Gereç ve Yöntem: Çalışmamızda, 300-400 gr arasındaki ağırlıkta olan Spragu…

Despite originally being described as a secreted protease, matrix metalloproteinase-2 (MMP-2) was recently revealed to have targets within cardiomyocytes. The biological mechanism(s) that describes the intracellular localization of MMP-2 is unknown and is thus the subject of thi…