Biomarker discovery and statistical modeling reveals the brain activity that supports brain function and dysfunction. Detecting abnormal brain activity is critical for developing biomarkers of disease, elucidating disease mechanisms and evolution, and ultimately improving diseas…
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In this thesis we investigate the mechanisms underlying the generation of abnormal EEG rhythms in epilepsy, which is a crucial step towards better treatment of this disorder in the future. To this end, macroscopic scale mathematical models of the interactions between neuronal po…
Brain-computer interface (BCI) research targets movement-free communication between the user and an electronic device using information encoded in the electrophysiological activity of the brain without involving neuromuscular pathways. In BCIs, voluntary modulation of the sensor…
Dual-process models of recognition memory propose that recognition memory can be supported by either a general sense of familiarity or the recollection of the encoding context. One source of evidence supporting dual-process models comes from event-related potential (ERP) studies…
Difficulties in speech production are often marked by disfluency; fillers, hesitations, prolongations, repetitions and repairs. In recent years a body of work has emerged that demonstrates that listeners are sensitive to disfluency, and that this affects their expectations for u…
Distraction during driving is one of the leading contributors to injury and mortality rates in traffic accidents. The aim of this current thesis was to consider 1) whether oculomotor and electrophysiological metrics could act as markers of cognitive distraction; 2) whether decre…
Schizophrenia is a neuropsychiatric disorder lying at the extreme of a spectrum of disorders that possibly share a common abnormality in neural connectivity. Efforts to reverse the core cognitive manifestations of schizophrenia using drug treatments have so far been unsuccessful…
The aims of the present thesis were two fold. The first aim was to investigate the relationship between self-referential and emotional processing. The second aim was to investigate the extent to which self-referential processing is altered as a function of mood. In order to addr…
Transcutaneous electrical nerve stimulation (TENS) is a simple, non-invasive technique used in the control of chronic pain. Despite the success of TENS and its continued use for over twenty years, some patients either fail to respond or show only a partial response. Furthermore …
The primary focus of this quantitative, quasi-experimental, repeated-measures, within-subject, counterbalanced research study was on the neurophysiology of religious prayer. Understanding both the neurophysiology and brain regions associated with religious prayer remains an impo…
The neural networks responsible for coordinating top-down self-regulatory processes, or executive functions, undergo intense fine-tuning and reorganization in early childhood. For children faced with prolonged stress (e.g., chaotic household environment, uncertainty) or adversit…