Homeostasis of the immune system is required for proper defense against pathogenic insult. Cells of the innate and adaptive compartments provide a strictly regulated response to clear infections while allowing for self-tolerance. Dysregulation of the components of the immune sys…
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Heterotrimeric guanine nucleotide-binding proteins (G proteins) transmit hormonal and sensory signals received by cell surface receptors to the intracellular effector proteins that regulate a number of cellular processes. Members of the highly conserved family of G protein α sub…
Adhesion of bacteria to host epithelial cells is a critical primary step in the pathogenesis of diarrheal disease. Bacteria demonstrating attaching and effacing (AE) adhesion include enteropathogenic Escherichia coli (EPEC), Verocytotoxin-producing E. coli (VTEC), and certain is…
Stimulus-secretion coupling in the pancreatic beta cell is mediated by different signalling molecules and involves a variety of ionic events including Ca2+-influx through voltage-gated Ca2+ channels and Ca2+ mobilization from intracellular stores. Inositol 1,4,5-trisphosphate (I…
The common human GNB3 825C > T variant, which is present in 50% of the world’s chromosomes, has previously been shown to predispose individuals to hypertension, cardiac and neural disorders. This variant causes the production of a stable and gain of function protein Gβ<sub>3S</s…
Plasma membrane calcium/calmodulin-dependent calcium ATPases (PMCAs) are high affinity calcium pumps regulating many calcium-dependent processes and advances in its characterisation have discovered that it may play a novel role in signal transduction pathways. It was the aim of …
G protein-coupled receptors transduce extracellular signals from a wide variety of ligands to regulate a broad range of physiological responses. This family of cell surface receptors share a conserved predicted tertiary structure consisting of seven membrane spanning domains fla…