The Trans-Iron Galactic Element Recorder (TIGER) was launched from Antarctica December of 2001 and flew for 31.8 days aboard a long duration scientific balloon. The objective of the TIGER experiment was to make a measurement of the elemental abundances of the Galactic Cosmic Ray…
The present study addressed whether milk fat, which was modified by partial replacement of saturated fatty acids (SFAs) with 18:1 would reduce plasma cholesterol (C). In addition, since dairy products contain high levels of calcium (cal), which may reduce C through an increased …
Stimulus-secretion coupling in the pancreatic beta cell is mediated by different signalling molecules and involves a variety of ionic events including Ca2+-influx through voltage-gated Ca2+ channels and Ca2+ mobilization from intracellular stores. Inositol 1,4,5-trisphosphate (I…
The purpose of this study was to understand the intracellular signaling pathways leading to myofibroblast contraction. Myofibroblasts generate the contractile force responsible for wound healing and pathological tissue contracture. While it has been proposed that the interaction…
The mammalian uterus plays a central role in the reproductive process. During pregnancy the organ undergoes a process of remodelling that is not restricted to a change in volume; its behaviour transitions from relative quiescence to regular contraction. This progression is incom…
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca²⁺ mobilising messenger in mammalian and non-mammalian cells. Studies on a variety of cell types suggest that NAADP evokes Ca²⁺ release from a lysosome-related store and via activation of a receptor distinct fro…
The growth of a neuronal dendritic tree depends on the neuron’s internal state and the environment within which it is situated. Different types of neuron develop dendritic trees with specific characteristics, such as the average number of terminal branches and the average length…
Lysophosphatidylcholine (LPC) is a by product of phospholipid metabolism, that under physiological conditions is maintained at a low level. However, through an enhanced degradation of phospholipids and/or a reduced catabolism, LPC accumulates in the plasma and fluids of patients…
Organic soils are found in many places around the world. Organic soils undergo large secondary settlements depending on the amount of organic matter present in the soil Organic soil is a mixture of finely divided particles of organic matter, in some instances visible fragments o…
Neuronal nicotinic-acetylcholine receptors (nAChRs) (e.g., α4β2, α7 Rs) appear to play critical roles in learning, memory, and various neuropathologies including nicotine addiction. Nicotine-upregulation of α7 Rs is thought to play a significant role in these phenomena. But whet…
Mineralization of vertebrate tissues such as bone, dentin, cementum, and calcifying tendon involves type I collagen, which has been proposed as a template for calcium and phosphate ion binding and subsequent nucleation of apatite crystals. Type I collagen thereby has been sugges…
Super-elastic scattering measurements were taken from calcium using the spectrometer described in this thesis. Calcium atoms were excited from the 41S0 ground state to the 41P1 excited state using a high resolution continuous wave laser set to a wavelength of 423 nm. A beam of e…