Statins are often the first-line therapy in the treatment of patients with hypercholesterolemia. Though often regarded as relatively low risk and widely effective in treating hypercholesterolemia, statin therapy has a variety of limitations, including statin resistance and stati…
"14" Result
Sort By:
Cardiovascular System is an organ and a primordial component in the human body and plays a principal role in the human health. In order to preserve the cardiovascular system, it was identified disorders or condition that can harm the cardiovascular system. The most common cardio…
Consumption of dietary saturated fats are a much debated topic of human nutrition and traditional recommendations have urged consumers to "avoid consuming saturated fat sources, such as butter and beef, to lower ones' risk of developing heart disease." Emerging evidence however …
The present study addressed whether milk fat, which was modified by partial replacement of saturated fatty acids (SFAs) with 18:1 would reduce plasma cholesterol (C). In addition, since dairy products contain high levels of calcium (cal), which may reduce C through an increased …
Coronary vascular disease (CVD) is the number one cause of death worldwide. According to a WHO report and global and regional projections of mortality and burden of disease, by 2030, the number of people dying from heart disease and stroke will increase to reach 23.3 million. No…
Investigated first was the effect of cholesterol status and dietary fatty acid profile on the expression of genes regulating hepatic cholesterol and lipoprotein metabolism. F1B hamsters were fed for 12 weeks diets enriched in 10% (w/w) coconut, olive or safflower oil in combinat…
Cardiovascular disease (CVD) is the leading cause of death and disability in the United States. Its genesis can be attributed, in part, to dietary and lifestyle patterns. Fat in the diet is comprised of different classes of fatty acids: saturated (SFA), monounsaturated (MUFA), p…
The liver X receptors α and β (LXR) are responsible for transcriptional regulation of a number of genes involved in cholesterol efflux from cells and therefore may be molecular target for the treatment of cardiovascular disease. However, the effects of LXR ligands on cholesterol…
Grain sorghum (GS) lipid has shown its ability to positively modulate plasma, hepatic cholesterol and gut microbiota in a hamster model. Responsible lipid ingredients as well as their target and off-target effects on cellular metabolism have not yet been studied as a potential s…
The fluidity and behavior of cellular membranes are typically controlled by the presence of sterol and other components. Lipid rafts (LR) are membrane micro-domains, which contain an unusually large amount of sterol and sphingolipid molecules. These domains have been associated …
Hawthorn fruit refers to the bright red berries of Crataegus species. It has a long history of use as a medicinal plant both in China and Europe. It has been claimed that consumption of hawthorn fruits is associated with long-term benefits on cardiovascular function. The hawthor…