Homeostasis of the immune system is required for proper defense against pathogenic insult. Cells of the innate and adaptive compartments provide a strictly regulated response to clear infections while allowing for self-tolerance. Dysregulation of the components of the immune sys…
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The effects of activation of protein kinase C (PKC) on intermediate filaments (IFs) of different cell types were investigated. In primary cultures of murine or rabbit spinal cord, or human fibroblasts, brief exposure to activators of PKC led to the following changes in IFs: (1) …
Phosphorylation of tyrosine residues has an important role in regulation of many processes including cell growth, cell differentiation and diverse physiological functions, This reversible process is controlled by two families of enzymes: protein tyrosine kinases (PTKs) and prote…
The contraction and relaxation of smooth muscle depends on the reversible phosphorylation of the 20,000 Da myosin light chains (MLC₂₀). The phosphorylation reaction, which is catalyzed by myosin light chain kinase and results in contraction, has been well characterized. In contr…