This thesis presents an investigation into the viability of utilising piezoelectric drop on demand printing as a tool for the deposition of proteins for the rapid prototyping of biological sensors. The work has focussed on several main aspects; the effect of printing parameters …
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In this study the heat-induced gelation of two (readily available) proteins, which contain disulphide bonds, has been investigated over a range of protein concentrations in the presence and absence of the presence of the reductant, dithiothreitol at neutral pH. The proteins sele…
The main focus of the PhD study was to develop new gel electrophoresis and ICP-MS based methods to analyze a wide variety of the bio-molecules such as proteins, phosphoproteins and metalloproteins etc. The tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis (tricin…
It is common for producers to utilize small grain companion crops when establishing perennial grasses and legumes, but research has historically focused on the use of small grain companion crops on the establishment of legumes. A study was established at three locations across N…
Primary Sjögren’s syndrome is an autoimmune disease, in which the immune system targets the exocrine glands. The disease is characterized by inflammation and dysfunction of the salivary and lacrimal glands, leading to dry eyes and mouth.
The Translationally Controlled Tumor Proteins (TCTPs) are a family of proteins whose functions are still largely unknown. The Plasmodium falciparum TCTP was first identified in studies of the mechanism of action of the antimalarial artemisinin. These studies demonstrated that TC…
Comparability assessments are frequently performed during biopharmaceutical drug development to evaluate the effects of manufacturing process changes on the structural integrity, safety and efficacy of candidate protein drug products. Physiochemical analytical evaluations (an es…
Lipid carriers such as emulsions and liposomes have been widely studied as carriers for different nutraceuticals. However, lipid carriers' physicochemical instability results in the leakage of loaded nutraceuticals and the low solubility into the digestion medium, thus reducing …
In chronic renal failure (CRF), urinary excretion of the products of protein metabolism, mainly urea, is markedly reduced due to a decrease in the glomerular filtration rate. Retention of these nitrogen metabolites has been associated with adverse clinical symptoms and may haste…
Bir çocuk birden çok yolla evreni algılamaya çalışır. Dünyaya gözlerini açar açmaz maruz kalınan uyarıcılar zihninde görsel ve işitsel bir çok yolla işlenmeye başlar (Piaget,1972). Peki ya işlenen bu verileri, öğrenciler bize gösterebilseydi nasıl olurdu? Bu araştırma, öğrenci ç…
Amaç: Çalışmanın amacı; dayanıklılık performansına yatkınlık sağlayan polimorfizmler aracılığıyla maratoncuların genetik profillerini değerlendirmek, beslenmenin ve genetik profilin spor performansındaki rolünü saptamaktır. Gereç Yöntem: Çalışmaya gönüllü 18-45 yaşlarında 23 erk…