Thesiss

Production of B lymphocytes in murine bone marrow is dramatically suppressed during pregnancy or after sustained exposure to estrogen and elevated in hypogonadol animals, suggesting that these hormones regulate the numbers of new cells produced (1–5). However, the stages of hema…

Syrian hamsters treated with 17 β-estradiol (E2) and testosterone propionate (TP) develop smooth muscle tumors (leiomyosarcomas) in the uterus or vas deferens at a frequency of 100%. Based on tissue culture experiment using vas deferens tumor cells (DDT1 cells), we hypothesized …

Aggression is a feature of many clinical disorders including autism, Alzheimer’s disease, bipolar disorder, and schizophrenia. The available treatment options act to prevent impulsive aggression through modulation of GABAergic and dopaminergic pathways which come with metabolic …

The purpose of the research was to study photoperiodism and endocrine control of reproduction in domestic turkeys. In female turkeys, plasma levels of luteinizing hormone (LH) were high at hatch, then declined to low levels at about 10 weeks of age, then rebounded to high levels…

Ovarian hormones act throughout the brain and body to influence a range of functions and behaviors. Estrogens and progesterone are neuroprotective and have important health implications. However, our understanding of the mechanisms underlying many of their actions is incomplete.…