Syrian hamsters treated with 17 β-estradiol (E2) and testosterone propionate (TP) develop smooth muscle tumors (leiomyosarcomas) in the uterus or vas deferens at a frequency of 100%. Based on tissue culture experiment using vas deferens tumor cells (DDT1 cells), we hypothesized …
A wealth of research has reported possible risk and predictive factors for dementia, the variance across populations and the possible reasons for this variance. This thesis attempts to describe demographic and modifiable risk factors for dementia, with the emphasis on the associ…
The complex process of wound repair becomes disrupted in the elderly with a profound effect on patient morbidity and huge financial implications for the NHS. While age itself is a risk factor for delayed healing recent work implicates estrogen decline, rather than intrinsic agei…
Breast cancer is major cause of morbidity and mortality globally and the incidence appears to be rising faster in population groups that hitherto experience lower incidence. This case control study recruiting 250 women with breast cancer and 250 age-matched controls from four Un…
Objectives . To examine associations between bladder cancer risk and (1) reproductive history-related estrogen exposure among Egyptian women, and (2) polymorphisms of the gene encoding the catechol estrogen-metabolizing enzyme, catechol-O -methyltransferase (COMT), among Egyptia…