Kerosene-based fuels have been used for many decades. Over 2 million military and civilian personnel each year are occupationally exposed to various jet fuel mixtures. Dermatitis is one of the major health concerns associated with these exposures. In the past, separate absorptio…
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Two types of hairless Peromyscus maniculatus mice (type-1 and type-2) were evaluated as an in vitro skin model for transdermal drug delivery studies and were compared to SKH-1 hairless mouse and human cadaver skins. The study contained the evaluation of the gender effect and the…
In this thesis, two potential applications of transdermal iontophoresis in the field of sports medicine were studied: (1) the local delivery of dexamethasone phosphate (Dex-Phos), a corticosteroid used to treat musculoskeletal inflammation, and (2) the extraction of systemic ami…
The nuclear hormone receptor (NHR) liver X receptor β (LXRβ) has been highlighted as a possible candidate for involvement in ageing by several recent findings. LXRβ is the closest human homologue to the longevity-associated gene daf-12 in the nematode worm and LXRβ haplotypes ha…
The complex process of wound repair becomes disrupted in the elderly with a profound effect on patient morbidity and huge financial implications for the NHS. While age itself is a risk factor for delayed healing recent work implicates estrogen decline, rather than intrinsic agei…
Skin, more specifically the outermost skin layer, the stratum corneum (SC), forms an extremely effective barrier, preventing both the loss of heat and water, and the ingress of micro-organisms and chemicals. Assessing the rate and extent of drug permeation into or through the sk…
My interdisciplinary dissertation seeks to reevaluate the ethics that are implicit in the way that wenarrate, or rather fail to narrate, experiences of mass or systemic violence, and the effect that such a failure wields on literature and contemporary political and social discou…
The controversial subject of blackness resides at the center of discussions of race in the Dominican Republic. Traditionally, scholars have painted the Dominican Republic as a society ignorant of its own history of blackness and devoid of a black consciousness. They argue that D…