Seismic time-lapse monitoring of subsurface fluid flow consists of acquiring multiple seismic surveys at a single site, repeated at time intervals in which interesting subsurface fluid movement can take place. Integrated with fluid-flow simulation, geology, rock physics and refl…
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Passive- and active-source seismological studies of northern Scotland and the South Caspian Basin indicate: (1) pervasive and laterally heterogeneous velocity discontinuities within the upper mantle influenced by the localized tectonic and thermal history of northwest Scotland, …
Contrast agents are used in over 35% of MRI scans today and their use is increasing as they become ever more sophisticated. The challenge for researchers in this field is to synthesise smart imaging agents, which can be addressed using more than one imaging modality. The ultimat…
Current methods for assessing the health of insects and their colonies are carried out by researchers making dissections on individual insects (which inevitably kills them) or making visual inspections of colonies and then documenting their observations. For colonies, researcher…
Humanitarian clearance of minefields is most often carried out by hand, conventionally using a a metal detector and a probe. Detection is a very slow process, as every piece of detected metal must treated as if it were a landmine and carefully probed and excavated, while many of…
This thesis presents a body of work on the theme of millimetre-wave FMCW radar, for the purposes of security screening and remote sensing. First, the development of an optimised software radar signal processor will be outlined. Through use of threading and GPU acceleration, high…
Silica nanoparticles are effective fluorophore carriers with high potential in imaging, diagnostics, and therapy. The particles are resistant to drastic change of environmental conditions (pH, temperature etc.) and insulate the dyes so as to protect them from photobleaching. Sil…
Soft tissue infection in a diabetic foot with an ulcer is often clinically obvious but the diagnosis of osteomyelitis underlying a diabetic foot ulcer is challenging. It has been calculated that there are over 1 million amputations worldwide for diabetes related complications ev…
Skin, more specifically the outermost skin layer, the stratum corneum (SC), forms an extremely effective barrier, preventing both the loss of heat and water, and the ingress of micro-organisms and chemicals. Assessing the rate and extent of drug permeation into or through the sk…
In this thesis the design and build of a high-speed, video-rate optical coherence tomography (OCT) imaging system is described. The system was designed for the purpose of imaging human skin in vivo, particularly that of patients suffering from conditions such as systemic scleros…
This thesis is concerned with the development of MOS charge-coupled device (CCD) technology for future applications in X-ray astronomy. Of particular interest is increased detection efficiency of high energy X-ray photons and increased pixel readout speed for large area sensors.…