Cognitive dysfunction is a core characteristic of schizophrenia, which can often persist when other symptoms, particularly positive symptoms, may be improved with drug treatment. The non-competitive NMDA receptor antagonist, phencyclidine (PCP), is a psychomotor stimulant drug t…
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The impact of fluorine in medicinal chemistry is reviewed in the first chapter of this work and the fluorine gauche effect, which has not been fully exploited in medicinal chemistry, is also discussed. GABAA and GABAB receptors are then presented and the synthesis of neurosteroi…
Brain development and function depend on intrinsic and extrinsic factors. In particular, the proper functioning of sensory systems can be altered according to the quality of extrinsic sensory information received during life. In this context, questions concerning neuroplasticity…
The circadian clock can be affected by a wide variety of drugs, hormones, and environmental conditions. For example, excessive alcohol intake may alter the normal phase (timing) of circadian rhythm, and may even abolish the expression of coherent circadian rhythms in human alcoh…