Thesiss

Cognitive dysfunction is a core characteristic of schizophrenia, which can often persist when other symptoms, particularly positive symptoms, may be improved with drug treatment. The non-competitive NMDA receptor antagonist, phencyclidine (PCP), is a psychomotor stimulant drug t…

Mammalian oocytes begin their meiotic division during embryonic life and arrest around birth at a G2-like phase of the cell cycle. These oocytes then enter a growth phase, during which they are not competent to resume meiosis. Meiotic competence is acquired by oocytes that have …

Phencyclidine (PCP) is a non-competitive NMDA receptor antagonist that has been shown to induce schizophrenia-like psychotic symptoms that are clinically indistinguishable from schizophrenia in patients. When administered to rodents, PCP produces an array of behaviours that are …