Thesiss

Cross-sectional evidence associates breakfast omission with negative health outcomes. The present work aimed to examine if these cross-sectional associations have a causal component, by conducting randomised control trials in healthy humans. It was established using lean individ…

Food intake is essential to all animals. However, when energy consumption through food overtakes energy expenditure, obesity can result. Obesity has been identified as a worldwide health problem associated with diseases such as type 2 diabetes and hypertension. Thus, it is essen…

Introduction: Appetite is often impaired in patients with gastrointestinal inflammation. Up to 75% of hospitalised Crohn's disease (CD) patients are malnourished. Recent animal research has suggested that immune mediated upregulation of enteroendocrine cell (EEC) activity plays …

Gut hormones are implicated in the regulation of energy balance. The studies in this thesis have examined the effects exercise on gut hormones (acylated ghrelin and peptide YY3-36), appetite and food intake, over extended durations. Sixty-nine young, healthy, predominantly Cauca…

In many rodent species, including Syrian hamsters, male reproductive behavior depends on the perception of odor cues from conspecifics in the environment. Volatile odor cues are processed primarily by the main olfactory system, whereas non-volatile cues are processed primarily b…