Experimental evolutionary studies are excellent approaches to study the coadaptation of the musculoskeletal with locomotor behavior in real time. My dissertation examines mice from 4 replicate High Runner (HR) lines bred for voluntary wheel running as young adults and their 4 no…
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This dissertation examines four immigrant novels. Two of their authors are Asian North Americans, whereas the other two are Hebrew writers, whose families moved from Arab lands to Israel. My thesis explores how the devouring imagery within these novels configure into the margina…
Why is bone sometimes used instead of ivory in Yorùbá carving? Bone objects are often mistaken for ivory, which is not surprising since the two materials look similar, although they are not identical. During interviews with Yorùbá practitioners carried out in Nigeria in the summ…
Tibial overuse injuries may arise following load-induced adaptive bone modeling and remodeling. The mechanism by which bone senses and adapts to its strain environment is enigmatic. While a dose-response relationship exists between the magnitude of applied strain and bone adapta…
Bone's ability to respond relatively high frequencies of mechanical stimuli is indicative as to how bone cells sense the signal for adaptation. This frequency sensitivity data extends beyond identifying the factor that stimulates bone formation. The most active inhibitor of bony…
Determining the postmortem interval (PMI) remains one of the most important but challenging factors to establish in a suspicious death investigation. Unfortunately, as time passes current methods lose accuracy and only allow investigators to approximate how long ago death occurr…
Introduction: Metaphyseal inwaisting is a process that occurs during long bone growth and remodelling of epiphyses and results in a proportional increase in growth plate width (GPW) and a decrease in metaphyseal width (MW). The Metaphyseal Index (MI) compares GPW to MW, usually …
A novel energy-based mechanistic model of nanoscratch test was derived to estimate the in situ toughness of bone using cube corner tip. In addition, several methodologies were developed to estimate the unknowns required by the model (i.e., shear angle, shear plane area, and the …
During the development of osteoarthritis (OA), subchondral bone undergoes substantial changes in structure and strength prior to the onset of cartilage damage. Consequently, bone anti-resorptive agents such as bisphosphonates have been investigated for possible mitigating effect…