Thesiss

Determining the postmortem interval (PMI) remains one of the most important but challenging factors to establish in a suspicious death investigation. Unfortunately, as time passes current methods lose accuracy and only allow investigators to approximate how long ago death occurr…

Articular cartilage has a limited capacity to heal due to the avascular nature of the tissue. A lesion that traverses the full thickness of cartilage and penetrates the subchondral bone plate will have access to subchondral blood flow. Blood-borne inflammatory mediators trigger …

During the development of osteoarthritis (OA), subchondral bone undergoes substantial changes in structure and strength prior to the onset of cartilage damage. Consequently, bone anti-resorptive agents such as bisphosphonates have been investigated for possible mitigating effect…