Thesiss

Background: COPD is characterised by increased neutrophilic inflammation which further increases during exacerbations. Corticosteroids are currently one of the mainstays of treatment but they have limited effectiveness; there is a great need to develop new anti-inflammatory phar…

COPD is associated with recurrent episodes of exacerbations that lead to ibcreased morbidity and mortality. Exacerbations are associated with increased airway and systemic inflammation. This thesis examines the relationship between the infective and inflammatory changes at each …

Healthcare delivery is facing a paradigm change to embrace rapid development in information technology, data analytics, artificial intelligence, as well as numerous medical devices and treatments to achieve smart and interconnected care.

Identifying latent subgroups in diseases with heterogeneous presentations can be difficult. It is clinically hypothesized that there are multiple types of patients prone to severe exacerbation in Chronic Obstructive Pulmonary Disease. Few studies have considered the longitudinal…

Background: Airways diseases comprise mainly of COPD and asthma. There is a need to develop both new models and improve methodologies of existing models these diseases. LPS challenges in smokers would be an excellent model to study the drugs directed against TLR4 mediated inflam…