Thesiss

Iron is an essential nutrient of cells and is utilized in metabolic processes and in cell proliferation. However, iron overload has been associated with increased risk for cancer, including breast cancer. Redox cycling of catecholestrogen metabolites between quinone and hydroqui…

3-Methylindole (3MI) is a selective pneumotoxicant that induces lung injury in all test animals. 3MI's pneumotoxicity is largely dependent on P450 bioactivation to produce 3-methyleneindolenine (3MEI). 3MEI is an unstable reactive intermediate that can readily alkylate macromole…