Thesiss

The overall aim of the research described in this thesis was to evaluate the effect of vitamin A supplementation on respiratory health, assessed by lung function in children aged 6–9 years. It comprises three studies. The first study determined the magnitude of vitamin A deficie…

The mechanisms of arsenic’s atherogenicity, toxicity and carcinogenicity remain to be elucidated. The lung is an established target of arsenic exposure. Therefore, the present studies address the effects of arsenic on the lung and examine the role of arsenic induced oxidative st…

3-Methylindole (3MI) is a selective pneumotoxicant that induces lung injury in all test animals. 3MI's pneumotoxicity is largely dependent on P450 bioactivation to produce 3-methyleneindolenine (3MEI). 3MEI is an unstable reactive intermediate that can readily alkylate macromole…