The PI3K-Akt signalling pathway is a well-established driver of cancer progression. One key process promoted by Akt phosphorylation is tumour cell motility; however the mechanism of VEGF-induced Akt phosphorylation leading to motility remains poorly understood. Previously, it ha…
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A class of model substrates that modulate the dynamic environment for a variety of cell adhesion and migration experiments was developed. The substrate is based on an electrochemically switchable self-assembled monolayer that presents redox active hydroquinone groups. In the pre…
The primary objective of this research was to identify and characterize tumor-related genes and transcriptional or signaling modulators that affect cell adhesion and motility, and to characterize their mode(s) of activity. Identification of pro-migratory genes is critical to our…
There is currently a lack of methods to prepare molecularly well-defined model substrates for studies of cell adhesion and cell migration. Most of these studies are performed on substrates that are coated with extracellular matrix proteins to which cells can attach. The limitati…
Cell migration is essential for embryonic development, it occurs in adult organisms during processes like wound healing and its misregulation contributes to pathological conditions such as metastasis. Despite this, most studies of cell migration have been undertaken in vitro. En…