The first comprehensive account of Diels-Alder reactions occurring by a simultaneous self-assembly of the components and catalysis of the reaction via a Lewis Acid (LA) is presented in this study. The synthetic usefulness of the intramolecularity achieved by temporary connection…
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A general synthetic approach to diterpenoids of the cis-clerodane family has been developed, culminating in the first total synthesis, in racemic form, of ({\pm})-6β-acetoxy-2-oxokolavenool (85) and ({\pm})-2-oxo-5α ,8α-13,14,15,16-tetranorclerod-3-en-12-oic acid (86). The key o…
There is currently a lack of methods to prepare molecularly well-defined model substrates for studies of cell adhesion and cell migration. Most of these studies are performed on substrates that are coated with extracellular matrix proteins to which cells can attach. The limitati…
In this thesis is presented work carried out during the course of the last 42 months. It concerns approaches towards total syntheses of the complanadine alkaloids. The main focus is the development of a model system to establish the viability of the key step in our proposed rout…