Thesiss

The matrix metalloproteinases (MMPs) play a key role in the physiological and pathological degradation of cartilage extracellular matrix (ECM). The tissue inhibitors of metalloproteinases (TIMPs) are specific endogenous inhibitors of the MMPs. 1. Transforming growth factor (TGF-…

Pulmonary fibrosis is an often fatal disease characterized by hyperplasia of interstitial cells and excessive accumulation of extracellular matrix components ultimately leading to remodeling of the lung architecture. The precise series of events leading to this scarring is yet t…