With the enactment of Bill C-3 (The DNA Identification Act) in December of 1998, Canadian law enforcement agencies will begin banking an annual estimate of 28,000 to 98,000 profiles (established using STR technology) obtained from individuals convicted of primary and secondary d…
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UHRF1 is an important epigenetic regulator of the human genome, which contains multiple chromatin binding domains. While its role in maintaining methylation patterns through the recruitment of DNMT1 to hemi-methylated DNA has been well established in mouse, less is known about i…
Oxidative phosphorylation couples ATP synthesis to respiratory electron transport. This coupling occurs in mitochondria, which carry DNA. Respiratory electron transport in the presence of molecular oxygen generates mutagenic reactive oxygen species (ROS) at a frequency that is i…
The application of ICP-MS to the fields of proteomics and genomics has arisen in part due to its ability to detect and quantify trace levels of S and P, which are major constituents in proteins and nucleic acids respectively. The development of collision/reaction cell technology…
One of the goals of structural DNA nanotechnology is to create larger more rigid structures that can be used as building blocks for two-dimensional arrays. Two-dimensional DNA crystals have been designed and constructed from Holliday junction analogues that have been combined in…
Austronesian is one of the major language groups spoken. It is believed that Taiwan, Indonesian (east of Wallace line), or Bismarck Archipelago is the star point for Austronesian migrations. It is also suggested that prehistoric cultures of Taiwan were established by the ancesto…
This dissertation consists of three main parts, totaling five chapters, and focuses on developing novel nucleosides via "click" chemistry and studying their potential biological properties. Chapter three describes the synthesis and properties of coumarin-modified fluorescent DNA…
This thesis reports voltammetric and quartz crystal microgravimetric studies of the binding of metal complexes to nucleic acids in solution and immobilised on metal surfaces. Cyclic voltam iet y and steady-state microelectrode voltammetsy were applied to the solution phase inter…
Sixty U.S. populations of Acroptilon repens collected in 1998 were analyzed using RAPD-PCR. Each population was represented by five specimens gathered from each location. A total of 301 specimens were examined using two Operon Technologies, RAPD-PCR primers (A 10 and C04). The D…
Catalysis plays an important part in our society. Numerous transition metal catalysts have been developed which can convert many different substrates in a wide range of reactions. Catalysis also plays an important role in nature and therefore special catalysts, enzymes, have evo…