Thesiss

Telomere dysfunction is one mechanism of cellular and tissue ageing. Dysfunctional telomeres in fibroblasts are recognised as DNA double-strand breaks (DSBs) and trigger the DNA damage pathway of senescence. However, telomere uncapping in normal human epidermal keratinocytes, vi…

Telomeres are physical ends of chromosomes consisting of (TTAGGG)n DNA sequence and a specialized set of proteins that protect chromosomal ends from degradation and from eliciting DNA damage response. These specialized set of proteins, known as shelterin, directly bind to telome…

Abstract not available.

DNA damage response (DDR) is a critical safeguarding system to protect genomic stability and integrality through a cascade of phosphorylation events of three PI-3-kinase-like kinases: ATM (ataxia telangiectasia mutated), ATR (ATM and Rad3 related), and DNA-PKcs (DNA-dependent pr…