The accurate replication of the mammalian genome is a complex and logistically challenging process. The entirety of the genome must undergo a single duplication with as little error as possible. This must occur in a coordinated fashion and over suitably short time scale so as to…
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Eukaryotic chromosomes are replicated from multiple replication origins which are activated according to a reproducible temporal program. In the following work, we undertook a genomic approach to the understanding of the regulatory determinants of the DNA replication timing prog…
DNA replication is a highly regulated process and governed by the cell cycle machinery, such that chromosomes are replicated once and only once per cell cycle. The question of what determines whether a DNA sequence serves as specific site for replication initiation is largely un…
DNA damage response (DDR) is a critical safeguarding system to protect genomic stability and integrality through a cascade of phosphorylation events of three PI-3-kinase-like kinases: ATM (ataxia telangiectasia mutated), ATR (ATM and Rad3 related), and DNA-PKcs (DNA-dependent pr…