Barley (Hordeum vulgare) is an economically important crop species with a large diploid genome. Around a half of the barley genome and a fifth of the genes are constrained within a low-recombining pericentromeric (LR-PC) region. I explored the LR-PC gene component with a genomic…
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This thesis explores some of the mechanistic links between replication factors and sub-telomeric sequences that confer the establishment and the inheritance of silencing at telomeres in Saccharomyces cerevisiae . I hypothesized that DNA replication factors affect telomeric silen…
A mean-field dynamical model of chromatin silencing in budding yeast is provided and the conditions giving rise to two states: one silenced and another un-silenced, is studied. Based on these conditions, the space of control parameters is divided into two distinct regions of mon…
Hox genes, dubbed the choreographers of animal development, lay out body plans by assigning positional identity to cells. In mammals, Hox genes are organized into compact gene clusters, with genes located close to one another. Due to their evolutionary history, the protein produ…
The Heterochromatin Protein 1 (HP1) family are a group of non-histone chromo- somal proteins with functions in many essential DNA processes. The HP1 family is high- ly conserved, and many eukaryotic genomes contain multiple HP1 genes. Individual pa- ralogs specialize in specific…
NF-κB signalling induces transcriptional upregulation of a wide array of genes in response to inflammatory signalling caused by, for example, TNFα cytokine. In addition to inducing the expression of factors which mediate an intracellular response, such stimuli also cause the exp…