Thesiss

This thesis explores some of the mechanistic links between replication factors and sub-telomeric sequences that confer the establishment and the inheritance of silencing at telomeres in Saccharomyces cerevisiae . I hypothesized that DNA replication factors affect telomeric silen…

The Origin Recognition Complex (ORC) is a heteromeric six-subunit protein complex that defines origins of DNA replication. ORC recognizes and binds to replication origins, serving as a scaffold for the assembly of replication initiation factors, therefore, it is a central compon…