Excipients present a challenge for oral drug bioavailability and it is recognized that excipient variability needs to be implemented in Quality by Design (QbD) approaches. The purpose of this thesis was to identify the biopharmaceutical implications of excipient variability on p…
Micronisation of active pharmaceutical ingredients (APIs) to achieve desirable quality attributes for formulation preparation and drug delivery remains a major challenge in the pharmaceutical sciences. It is therefore important that the relationships between crystal structure, t…
Surface/interface equilibration and wettability modification of organic liquids are two important phenomena in many practical applications including subsurface remediation, detergency and food industry. Although surface/interface equilibration and wettability are two different p…
Dissolution of soluble substrates such as gypsum presents a major hazard to dams in many parts of the world. This research simulates hypothesised conditions beneath the Mosul Dam, northwest Iraq, where collapse of a karstic system associated with continuous fresh water supply fr…