Thesiss

Excipients present a challenge for oral drug bioavailability and it is recognized that excipient variability needs to be implemented in Quality by Design (QbD) approaches. The purpose of this thesis was to identify the biopharmaceutical implications of excipient variability on p…

Over recent years the delivery of nanosized drug particles has shown potential in improving bioavailability. Drug nanosizing is achieved by 'top-down' and by 'bottom-up' approaches. Owing to limitations associated with the top-down techniques, such as high energy input, electros…

Solid dispersions of crystalline drugs in polymer matrices are promising as an approach to improve bioavailability. However, the high energy of amorphous drug in a solid dispersion leads to crystallization. In this work, the Flory-Huggins Theory predicts the solubility of crysta…