Thesiss

Systems biology attempts to understand biological systems through the generation of predictive models that allow the behaviour of the system to be simulated in silico. Metabolic systems biology has in recent years focused upon the reconstruction and constraint-based analysis of …

I uncover several global trends that shape the global distribution of important metabolic parameters. Evolutionary pressures and physicochemical constraints that account for these trends are suggested. Analyzing the kinetic parameters of enzymes I find that the "average enzyme" …