Thesiss

This study focuses on the development of a new paper-based microfluidic device for the detection of IαIP via ELISA. Recent studies proved that the concentration of IαIP is related to the mortality rate of patients who suffer from sepsis. The developed device is able to determine…

Particle/cell analysis is crucial in many health, industrial and environmental monitoring processes. Its integration into miniaturised lab-on-a-chip systems enables a host of portable technologies. However, current lab-on-a-chip lithographical fabrication methods are costly, tim…

This thesis focuses on inductive base sensor design at MHz range frequency. The background theory, design, experiments and results for a new magnetic particles sensor is presented. A new magnetic sensor based on a planar coil was investigated for DNA pathogen detection. Change i…

Integration and miniaturisation in electronics has undoubtedly revolutionised the modern world. In biotechnology, emerging lab-on-a-chip (LOC) methodologies promise all-integrated laboratory processes, to perform complete biochemical or medical synthesis and analysis encapsulate…

A magnetic bead-based DNA extraction and purification device has been designed to be used for extraction of the target DNA molecules from whole blood sample. Mixing and separation steps are performed using functionalised superparamagnetic beads suspended in the cell lysis buffer…

In this research, we explore the possibility of improving the efficiency of Dean vortex-based mixers by only employing smooth-walled simple two-dimensional (2D) geometries. Numerical simulation results reveal that the symmetries of Dean flows in the prevalent "S-shaped" mixers c…

Optical biosensors are increasingly being considered for lab-on-a-chip applications due to their benefits such as small size, biocompatibility, passive behaviour and lack of the need for fluorescent labels. The light guiding mechanisms used by many of them result in poor overlap…