Thesiss

Friedreich ataxia (FRDA) is an autosomal recessive, neurodegenerative disorder with severely debilitating effects and no current cure. FRDA is mainly caused by the hyper-expansion of a GAA repeat present in intron 1 of the FXN gene, which results in decreased gene expression and…

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterised by deficits in language, behaviour and memory. Increasing evidence suggests that mid-life obesity and a diet high in fat are risk factors for AD. In contrast, life-threatening weight loss occurs …

Celiac disease (CD) is an immune-mediated enteropathy triggered by glutens in wheat, barley, rye, and possibly oat in individuals carrying HLA DQ2.5 or DQ8 genes. Lifelong avoidance of specific glutens is the only effective treatment for CD consumers. Homologous proteins from ot…