Thesiss

This thesis describes investigations into the genetic basis and pathophysiology of three distinct inherited diseases in humans, two of which are strongly associated to the function of the ectodomain sheddase enzyme ADAM17. The first of these is a novel inherited syndrome of neon…

Problem: Postoperative delirium is a large problem in critical patients leading to negative long-term impacts on patients including cognitive impairments and increased length of hospital stay leading to increased morbidities. This in turn results in increased hospital costs. Pos…