Thesiss

Enzymes are powerful biological catalysts that provide rate accelerations of up to 1019 times the rate of the uncatalysed reaction in water by lowering the activation energy of the reaction. Enzymes also have an extraordinary specificity for reacting substrates, which can distin…

The paralogous multi-functional adaptor proteins YAP and TAZ are nuclear effectors of the Hippo pathway, a central regulator of developmental organ size control, tissue homeostasis and tumour suppression. YAP/TAZ target the TEAD transcription factor family to promote cell surviv…