Thiosemicarbazones are a class of compounds which have been extensively studied for their anti-proliferative biological properties. The biological properties include antitumor, antibacterial, antiviral and antimalarial, with many diseases studied and reported in the literature. …
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In this dissertation, the problem of the Joint Time-Frequency (JTF) transforms is addressed with the objective of developing linear critically-sampled JTF transform with optimal characteristics, namely being stable and having the biorthogonal function and the analysis function b…
This dissertation presents three methods for evaluating formation permeability using log data in the CTR field, Saudi Arabia. The first method used the concept of hydraulic flow units (HFU's). The second method derived formation permeability using neural networks and log data. T…
The bis-naphthalimidopropyl drugs DMP8408, BNIPDaoct and BNIPDanon, have been developed as novel synthetic lead compounds in cancer therapy. Biochemical assays of these compounds have demonstrated high inhibitor activity (IC50=0.8–1.8μM) against cancer cells, which makes them th…
Many thousands of pounds are spent every year by pharmaceutical companies on understanding the mechanisms and kinetics of chemical reactions involved in drug discovery and production. NMR spectroscopy is often at the core of these studies as it is a powerful, non-destructive met…
In this project a number of peptidyl transferase antibiotics were studied, specifically a group of aminohexose cytosine nucleoside antibiotics and their interaction with a selected number of highly conserved ribonucleic acid (RNA) motifs, designed to represent their possible bin…
The paralogous multi-functional adaptor proteins YAP and TAZ are nuclear effectors of the Hippo pathway, a central regulator of developmental organ size control, tissue homeostasis and tumour suppression. YAP/TAZ target the TEAD transcription factor family to promote cell surviv…
The area of art conservation presents many interesting problems in analytical chemistry. This work describes studies of four applications of nuclear magnetic resonance to problems in art conservation. A new double quantum filtered internal DOSY NMR experiment was developed and t…
The main theme of this dissertation concerns the study of the properties of zeolites and modified zeolites with respect to reactivity and catalysis by way of MAS NMR and theoretical modeling with Density Functional Theory (DFT). The combined use of MAS NMR and DFT to study zeoli…
Roemeria refracta of Turkish origin had formerly provided a number of alkaloids suspected of belonging to the pavine-isopavine grouping. As a result of the present effort, it was demonstrated that one of these bases, (-)-eschscholtzinone, is the first ketonic pavinoid. (-)-Norre…
This thesis describes the isolation and structure elucidation of secondary metabolites from a number of endophytic Xylaria fungi. Six Xylaria endophytes were surface cultured on an aqueous malt extract-glucose medium. The fungus A311R, from a palm tree in Thailand, produced nona…
The history of the World could not be told without mentioning specialized metabolites. Long before we had the notion of organic molecules, we were already sailing across the oceans in the pursue of their valuable sources, and raising whole empires based on the economy of spices,…
The ability of surfactants to form micelles and solubilise hydrophobic substances in aqueous environments has been widely exploited in formulation science. In spite of extensive studies over the past few decades by both experimental and theoretical methods, however, it remains d…
Type IV pili, or fimbriae, are long, thin proteinaceous appendages found on the surface of many well-known pathogens. They mediate a variety of important virulence functions for the organism, such as twitching motility, biofilm formation, uptake of genetic material and host cell…