Thesiss

Advanced therapy medicinal products (ATMPs), which include cell and gene therapies, have the potential to revolutionise the healthcare industry through curing conditions which have previously been manageable at best. ATMP developers face challenges due to the complexity of their…

Immune thrombocytopenia is a blood disorder, characterised by low platelet count, bleeding and bruising. In children, symptoms are generally mild and spontaneous remission is common. Literature relating to other paediatric conditions is reviewed and considered alongside limited …

This study investigated the role of NMDARs in the differentiation of MEG-01 cells and in the activation of human platelets. This investigation demonstrated that the NR1, NR2D and NR3 subunit proteins are expressed in human platelets, with the NR1 subunit also expressed in MEG-01…

Neuroinflammation is an important contributor to the pathogenesis of many neurological diseases. A key component of the innate immune response in the central nervous system is the migration of neutrophils into the brain parenchyma, where they exacerbate neuronal injury and worse…