Thesiss

Rationale: Chronic cough (cough >8 weeks) is common, leads to an impaired quality of life, and is difficult to treat. Despite intensive investigation, ~40% of patients referred to a specialist cough clinic will remain resistant to treatment targeted at peripheral triggers such a…

This study investigated the role of NMDARs in the differentiation of MEG-01 cells and in the activation of human platelets. This investigation demonstrated that the NR1, NR2D and NR3 subunit proteins are expressed in human platelets, with the NR1 subunit also expressed in MEG-01…

Until recently, the accepted view of synaptic integration in most CNS neurons, including pyramidal neurons of the neocortex, has involved the vague notion that neurons "sum" their inputs from across their entire dendritic trees in some simple (e.g. linear) way, and fire action p…