Boron neutron capture therapy (BNCT) for the treatment of prostate cancer using a boron-containing cholesteryl ester compound (BCH) was investigated. BNCT is a binary radiation therapy that relies on targeted delivery of 10B to cancer cells followed by irradiation with thermal n…
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Vitamin D3 (VD3) is a fat soluble secosteroid obtained primarily through ultraviolet-B dependent synthesis in the skin. VD3 has antitumor effects and has been suggested to reduce risk of non-skin cancers. The vitamin D receptor (VDR) has shown inconsistent association with prost…
Native-born (born in the United States) and Caribbean-born African-American males bear a disproportionate burden of prostate cancer morbidity and mortality. However, few studies have examined differences between Native-born males and Caribbean-born African-American males, and th…
RRR-α-tocopheryl succinate (VES) is known to inhibit the proliferation of numerous cancer cell types. Previous studies have illustrated VES's ability to induce DNA synthesis arrest, increase activation of latent transforming growth factor-β (TGF-β), and promote apoptosis. Three …
Nucleolin, an abundant cellular protein, has been recognized as a therapeutic target in gene therapy treatments for cancer. Structural studies to facilitate rational design of small molecule inhibitors of nucleolin require sufficient quantities of the protein. Since cellular lev…
Prostate cancer (PCa) is the fifth leading cause of cancer-related deaths amongst men worldwide. Androgen deprivation therapy (ADT) in combination with radiation therapy (XRT) is the standard of care for high-risk localized PCa. Unfortunately, most patients become resistant to A…
Two significant limitations of tissue specific replicative adenovirus (TSRAd) for cancer virotherapy are limited target specificity and efficacy. We have developed a TSRAd with a "Double Lock" mechanism to provide tighter transcriptional control. This was accomplished by placing…
"'Come to bed with me?' 'Huh? No, I'd rather read this book about cancer ... ' As soon as Bob was diagnosed with aggressive prostate cancer, he and his wife Elizabeth started making cancer jokes to take the edge off of an otherwise awful situation. A lot of those jokes were abou…
"'Come to bed with me?' 'Huh? No, I'd rather read this book about cancer ... ' As soon as Bob was diagnosed with aggressive prostate cancer, he and his wife Elizabeth started making cancer jokes to take the edge off of an otherwise awful situation. A lot of those jokes were abou…