Giardiasis, cause by the parasitic protozoan Giardia duodenalis, is one of the most common infectious gastrointestinal diseases in humans worldwide. However, its true population burden and epidemiology and in particular its zoonotic transmission potential are still poorly unders…
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High throughput sequencing can generate hundreds of millions of reads in a single day and is revolutionizing modern genetics. This project aimed to utilize next generation genetic approaches to analyze non-model but important agronomical plant species. A key feature of these spe…
Visual perception is highly variable across healthy individuals and increasing evidence suggests that this inter-individual variation could be due to differences at the genetic, neurochemical, structural and neurophysiological level. Specifically, variation in the GAD1 gene (res…
This thesis provides a detailed study of the diet of various procellariiformes using new molecular approaches. Dietary studies remove fundamental blocks to our understanding of the structure of food webs, and provide insights into the demographic regulation of populations and th…
ChlR1 is a DNA helicase implicated in diverse cellular processes including sister chromatid cohesion and DNA replication and repair. However, the mechanism by which ChlR1 participates in these processes is unknown. Data presented in this thesis show that siRNA-mediated depletion…
Replication of the genome is a central process in cellular life, which must be tightly regulated at the risk of genomic instability. DNA replication has been extensively studied in bacteria and eukaryotes, and recently, in archaea. Universally, DNA replication is started at spec…
Steroids play a major role in the development of the CNS with those brain areas involved in sexual behaviour having been the focus of most neuroendocrine studies to date e.g. the hypothalamus and pituitary gland (Feist and Schreck, 1996; Mong, et al., 1999; Toran-Allerand, et al…
Histone modifications form an important part of the epigenetic landscape that controls many aspects of cellular function, including regulation of gene expression and cell differentiation. The persistence and inheritance of many of these modifications through the cell cycle and d…
Signal transduction pathways are mainly depending on phosphorylation events, which are controlled by the activity of phosphatases and kinases. Although kinases have been widely studied, however, much less is known about the contribution of phosphatases to the regulation of cell …
The field of science whose goal is to assign each input object to one of the given set of categories is called pattern recognition. A standard pattern recognition system can be divided into two main components, feature extraction and pattern classification. During the process of…
Studies of spider silks indicate that they may outperform virtually all synthetic fibres in terms of strength, elasticity and toughness. To date, most silks studied come from only a select few species and likely underrepresent the immense diversity of the clades. Here, protein a…
The work described in this thesis concerns the design, synthesis, DNA binding and biological activity of palladium(II) supramolecular cylinders that might be capable of recognizing a DNA four-way junction. An introduction to DNA structure will be presented, as well as the differ…
Arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome is a severe multisystem disorder caused by mutations in VPS33B and VIPAR. A splice site mutation, VPS33B c.1225+5 G>C, was identified in a patient with attenuated ARC phenotype. Modelling of this mutation and misse…
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are a family of proteins that are closely related to the matrix metalloproteinases (MMPs). It has been suggested that the proteins have a critical role in the breakdown of articular cartilage during osteoart…
In Guinea-Bissau (GB) the Guinea baboon (Papio hamadryas papio) is threatened by hunting pressure. Along with local extinctions, these practices may be inducing long-term genetic changes and disrupting underlying social structure. In this study, the bushmeat trade in GB was eval…
In cell populations there is a great deal of heterogeneity. Cells can be seen to react different to the same stimulus despite being the same cell type and under the same conditions. Single cell analysis of a population is, therefore, crucial to understanding the nature of these …
Colorectal cancer is one of the most clinically significant types of cancer due to both high incidence and mortality. Despite the well-established role of aberrant Wnt signalling in initiation and progression of colorectal cancer, therapies that specifically target the Wnt pathway…
Familial renal cell carcinoma (RCC) only accounts for 3% of all RCC, yet the study of these inherited forms has provided important insights into the more common sporadic RCC. Somatic VHL inactivation is found in 70% of sporadic clear cell RCC (ccRCC) though is rarely found in ot…
Clonal cell populations are known to exhibit marked phenotypic heterogeneity at the single cell level, a phenomenon usually masked by conventional population-wide analyses. Two models of yeast cell heterogeneity were investigated during this study. First, expression of the Sacch…