Thesiss

The overall aim of this thesis was to try to predict individuals with Juvenile Idiopathic Arthritis (JIA) who do not respond to a drug called methotrexate (MTX). The clinical information from individuals recruited to four national JIA studies was combined for collective analysis…

The aim of this thesis is to explore the role of common genetic variation, identified through genome-wide association (GWA) studies, in human traits and diseases, using height as a model polygenic trait, type 2 diabetes as a model common polygenic disease, and maturity onset dia…

Precision medicine approaches have promise to improve the prevention and treatment of cardiovascular disease, which is the leading cause of death in the United States and globally. As the size and number of electronic health record (EHR)-linked biobanks with paired genetic infor…