Thesiss

Protein-tyrosine phosphatase 1B (PTP1B) and T cell protein-tyrosine phosphatase (TCPTP) are structurally similar cytosolic proteins that are implicated in the regulation of metabolism. PTP1B is an important physiological regulator of glucose homeostasis and energy balance and th…

Congenital Hyperinsulinism in Infancy (CHI) is a potentially lethal disease that leads to severe hypoglycaemia in children due to the impaired insulin release by β-cells. The disease is genetically and histologically heterogeneous; however, a complete understanding of the islet …

It is well established that diabetes is of critical importance in the world as the number of people affected increases globally. Although a great deal is known about the pancreas and its function, there are still unanswered basic questions about normal pancreatic physiology/func…