The reinforcing properties of nicotine depend partly on cholinergic projections from the pedunculopontine tegmental (PPTg) and laterodorsal tegmental (LDTg) nuclei to midbrain dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). Neuronal…
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Tobacco is a plant that is native to the Americas, where it has grown before and throughout human occupation of these continents. Tobacco is used for communication with and offerings to gods and spirits, to treat illness, to solidify relationships among communities, and for enjo…