Soon after the discovery that TRR was a selenoprotein Hill et al. showed that TRR activity decreased more than 90% in 14 wk old Se-deficient rats (Hill et al. 1997). To date, however, there are no reports of Se regulation for TRR message in vivo. Therefore, our objective was to …
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A series of Pt(S₂N₂)(P(OR)[subscript n]R′[subscript(3-n)])₂ complexes were prepared and analysed using ³¹P NMR and IR spectroscopy, elemental analysis and X-ray crystallography. Similarly, a series of Pt(SeSN₂)(P(OR)[subscript n]R′[subscript(3-n)])₂ complexes were also prepared …
Platinum-based drugs are an important group of alkylating-like agents which are used in cancer chemotherapy treatment. Cisplatin and oxaliplatin in particular are still commonly used today and are the focus of this thesis. As with most chemotherapy drugs, the efficacy of these d…
The environmental, microbiological and technological aspects of selenium is explored with the aim of assessing and identifying microorganisms capable of interacting with Se in the environment and forming functional 'bionanomaterials'. To determine the natural microbial response …
Exposure to arsenic (As)-contaminated drinking water affects tens of millions people worldwide. The health effects of As are well established yet the mechanisms and dose-response relationships of As toxicity are not fully understood. Inaccurate exposure assessment, limited sensi…
Supplementation of selenium (Se) has been shown to have important hypocholesterolemic properties in animal experiments and in some human trials; however, underlying mechanisms remain unclear. One possible mechanism may be via the liver X receptor (LXR) pathway that lowers intest…
Introduction. Chronic arsenic (As) exposure currently affects more than 100 million people worldwide. The studies reported in this dissertation focus primarily on determining if arsenic (As) exposure is associated with genomic DNA methylation and if this association is modified …
The Pleurotus eryngii species complex comprises at least five varieties: eryngii, ferulae, elaeoselini, nebrodensis and tingitanus . This species is unique among the genus Pleurotus because in nature it is found in association with specific members of the Umbelliferae and Compos…
Four hundreds and eighty male turkeys (12-week-old, raised on a corn-soybean basal diet) were randomly fed 8 experimental diets supplemented with none (Control, Con), 200 IU/kg vitamin E (VE), 0.3 ppm Se (Se), 2.5%CLA (CLA), 200 IU/kg vitamin E+0.3 ppm Se (VE+Se), 200 IU/kg vita…
Selenium (Se) is a trace element of great ecological importance whose environmental distribution is highly impacted by anthropogenic activity. In the 1980s, selenium was recognized as a major aquatic contaminant following widespread deformities and mortality among waterfowl hatc…
TiO2 assisted photocatalysis using artificial and solar radiation and solar photo-Fenton processes were employed for the removal of aqueous phase selenite and selenate species in conjunction with EDTA as a hole scavenger. For the UV-lamp light assisted photocatalysis, faster rem…
it was proposed that antagonistic effects noted between selenium and arsenic might be leveraged through the dispensation of selenium dietary supplements in arsenic-afflicted regions. (A full discussion of arsenic toxicity, selenium in human health, and prior knowledge of seleniu…
Mercury-selenium (Hg-Se) interaction is perhaps the most documented bioantagonism. Since its discovery in the 1960s, extensive studies have been carried out on the wide occurrence, chemical mechanisms, and toxicological significance of this bioantagonism. However, major knowledg…
The first chapter of this thesis describes the development of a general route for the generation of selenium stabilized carbanions via a method that bypasses acid catalyzed formation of selenoacetals. Aldehydes are first converted into α- hydroxystannanes by nucleophilic additio…