Mouse models for drug discovery: methods and protocols
by Proetzel, Gabriele Wiles, Michael V.
With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various behavioral models. Written for the highly successful Methods in Molecular Biology…
Read More ↓Title Statements
- Full title :Mouse models for drug discovery : methods and protocols / edited by Gabriele Proetzel and Michael V. Wiles.
Summary
With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various behavioral models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Read More ↓Edition Statements
- Publication Date:2016
- Edition:Second edition
Publication Statements
- Publisher(s):Springer
- Place of Publication:New York
- Language:eng
- Publication Date:2016
Notes
Previous edition: Totowa, N.J.: Humana, 2010.
The Physical Object
- Description:xi, 436 pages : : illustrations ; : 27 cm.
Edition Identifiers
- ISBN:9781493936595, 149393659X
- oclc:ocn961478178
- Dewey Decimal:615.580724
Table of Contents
Machine generated contents note: 1. Genetically Defined Strains in Drug Development and Toxicity Testing / Michael F.W. Festing -- 2. Simple, Efficient CRISPR-Cas9-Mediated Gene Editing in Mice: Strategies and Methods / Michael V. Wiles -- 3. Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice / Michael V. Wiles -- 4. Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells / Michael A. Brehm -- 5. Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens / Alexander Ploss -- 6. Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies / Thomas J. Sproule -- 7.A Humanized Mouse Model to Study Human Albumin and Albumin Conjugates Pharmacokinetics / Michael V. Wiles -- 8. Germ-Free Mice Model for Studying Host-Microbial Interactions / Puma C. Kashyap.
Note continued: 9. Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans / Teresa P. DiLorenzo -- 10. Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery / Helene Baribault -- 11. Cholesterol Absorption and Metabolism / Ph…
Subjects
Writers
More from this Series
No reviews yet. Be the first to rate this work.
Related Works
more →
G protein-coupled receptors in drug discovery
Microarray methods for drug discovery
Microarray methods for drug discovery
INTERFACE BETWEEN REGULATION AND STATISTICS IN DRUG DEVELOPMENT
ALEMAYEHU, DEMISSIE. EMIR, BIROL. GAFFNEY, MIKE
Vaccine design: methods and protocols
Anticancer drug development
G protein-coupled receptors in drug discovery
G protein-coupled receptors in drug discovery
G protein-coupled receptors in drug discovery
G protein-coupled receptors in drug discovery
Files & Downloads
-
Mouse Models for Drug Discovery: Methods and Prot…
PDF · 10.7 MB · updated
Rate & Review