This thesis discusses the development and synthesis of ligands for coordination to dand f- block metal ions. The subsequent coordination chemistry to PtII and a range of LnIII metal ions is outlined, along with the photophysical properties of the resultant compounds towards bimo…
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The coordination chemistry of phosphine ligands was pioneered by Mann, Chatt, and others beginning in the 1930s.1 Currently, phosphine compounds are sought as one of the most important classes of L-type ancillary ligands for transition metal complexes, particularly, because of t…
This thesis describes the use of both sulfuric acid and triflic acid, to promote hydroamination and hydroalkoxylation cyclisations for the formation of N- and Oheterocycles. Chapter 2 describes the synthesis of 2,2,6-trisubstetuted piperidine. A wide range of protecting groups h…
Syntheses, spectroscopic and microporosity analysis of novel phthalocyanines and porphyrin containing molecules and polymers were carried out. For this purpose, various bulky substituents were introduced on to the aromatic core in order to provide an awkward shape and hence avoi…
Preclinical bioluminescence tomographic reconstruction is underdetermined. This work addresses the use of prior information in bioluminescence tomography to improve image acquisition, reconstruction, and analysis. A structured light surface metrology method was developed to meas…
Mammalian skin is a highly-specialised organ, providing a robust barrier against environmental challenges. In order to maintain functional integrity and a healthy state, the skin’s constituent tissues undergo continuous renewal, controlled by finely-controlled homeostatic mechan…
Within this thesis we explore the synthesis and modification of hierarchical composite particles and responsive microgels. Initially in Chapter 2 we describe the encapsulation of calcium carbonate particles within a polymeric shell, wherein the inorganic core is kinetically trap…
In this thesis the one-pot subcritical hydrothermal synthesis of several novel complex oxides with potential applications in catalysis is reported. The hydrothermal synthesis of nanocrystalline pentavalent ion-substituted cerium dioxide is reported. The materials were all charac…
Bioactive peptides are short (2-50 residues) sequences of amino acids that exhibit a single or multiple activities that can have an impact on biological systems. They can be derived from a variety of sources that include dietary proteins, which release peptides during digestion …
Asbestinins are the most complex of the ether bridged 2,11-cyclised cembranoids, isolated from the gorgonian octocoral species Briareum asbestinum. They have a complex rigid tetracyclic framework with nine or more contiguous stereocentres and a highly substituted tetrahydrofuran…
Peptides are crucial in biological processes: depending on their structure and location in the body they play different important roles. In vivo, peptides can be cleaved by proteases that degrade and reduce their activity. Studies have shown that peptide bonds can be mimicked in…
The search for life beyond Earth, and on Mars in particular, is one of the key points of astrobiology research. However, space missions are expensive and time-consuming. Simulating such missions at analogue sites on Earth can thus save time and money whilst working in natural se…
In this work, an alternative strategy involving a fully synthetic approach is being investigated toward structure-based vaccine design against HCV. The main focus is being put on the HCV envelope E2 glycoprotein, which is a viral protein that is present on the outside of the vir…
During the course of this PhD, several libraries of potential PET imaging agents were synthesised for testing their affinity and selectivity for sphingosine-1-phosphate 5 receptors (S1P5). These receptors are located within oligodendrocytes and are proposed to have a major role …
Renewable and sustainable energy are developed to address global energy demand which has increased dramatically. Among them, syngas/producer gas, defined as a gas fuel consisting of hydrogen (H2), carbon-monoxide (CO), carbon dioxide (CO2), water vapour (H2O), nitrogen (N2), and…
This study attempts to insert critical thinking practices in the secondary chemistry classroom, specifically Years 9 and 10. Critical thinking is a concept elusive in nature, with several definitions, addressing both the disposition and the skills of an aspiring critical thinker…
Phosphaszene based organocatalysis was applied to prepare oligocarbonate from CO2 and cyclohexane oxide under very mild conditions. Modification of experimental conditions such as temperature, reaction time and co-catalyst content, reveal that the oligoccarbonate is a result of …
Arsenic exhibits diverse chemical reactivity depending upon its oxidation state. This distinctive reactivity has been largely overlooked in the field of polymer and biomaterials science, owing to concerns about the toxicity of arsenic. However, a recent clinical renaissance in t…
Reversible deactivation radical polymerisation represents a versatile route to prepare well-defined polymeric materials with complex architecture, controlled molecular weight and tuneable end-groups. RDRP techniques have now been translated to heterogeneous polymerisations (emul…